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spatial gene expression heatmaps  (Spatial Transcriptomics Inc)
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Spatial Transcriptomics Inc spatial gene expression heatmaps
RNA and protein distribution for reactive gliosis markers in CTE lesion sulcus. a Spatial gene expression <t>heatmaps</t> generated from the Visium spatial transcriptomics data illustrates the mRNA distribution for NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) within a lesion sulcus for CTE case AU6 from the Australia Sports Brain Bank. b Immunohistochemistry was performed for the corresponding protein in (a) on a different lesion sulcus from the same case. The p-tau (AT8) labelling for the same tissue sections is shown at the bottom (c–d) . Scale bar: 200 µm. In all three cases, focal increases in NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) mRNA and protein expression are seen in cortical layer 1, the white matter and within the lesion area (yellow arrow) where AT8 tau is highly concentrated. The sulcal border is marked with an asterisk
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RNA and protein distribution for reactive gliosis markers in CTE lesion sulcus. a Spatial gene expression heatmaps generated from the Visium spatial transcriptomics data illustrates the mRNA distribution for NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) within a lesion sulcus for CTE case AU6 from the Australia Sports Brain Bank. b Immunohistochemistry was performed for the corresponding protein in (a) on a different lesion sulcus from the same case. The p-tau (AT8) labelling for the same tissue sections is shown at the bottom (c–d) . Scale bar: 200 µm. In all three cases, focal increases in NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) mRNA and protein expression are seen in cortical layer 1, the white matter and within the lesion area (yellow arrow) where AT8 tau is highly concentrated. The sulcal border is marked with an asterisk

Journal: Acta Neuropathologica

Article Title: Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy

doi: 10.1007/s00401-025-02854-x

Figure Lengend Snippet: RNA and protein distribution for reactive gliosis markers in CTE lesion sulcus. a Spatial gene expression heatmaps generated from the Visium spatial transcriptomics data illustrates the mRNA distribution for NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) within a lesion sulcus for CTE case AU6 from the Australia Sports Brain Bank. b Immunohistochemistry was performed for the corresponding protein in (a) on a different lesion sulcus from the same case. The p-tau (AT8) labelling for the same tissue sections is shown at the bottom (c–d) . Scale bar: 200 µm. In all three cases, focal increases in NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) mRNA and protein expression are seen in cortical layer 1, the white matter and within the lesion area (yellow arrow) where AT8 tau is highly concentrated. The sulcal border is marked with an asterisk

Article Snippet: Fig. 3 RNA and protein distribution for reactive gliosis markers in CTE lesion sulcus. a Spatial gene expression heatmaps generated from the Visium spatial transcriptomics data illustrates the mRNA distribution for NQO1, CHI3L1, GFAP, AQP4 and FTL (L-ferritin) within a lesion sulcus for CTE case AU6 from the Australia Sports Brain Bank. b Immunohistochemistry was performed for the corresponding protein in (a) on a different lesion sulcus from the same case.

Techniques: Gene Expression, Generated, Immunohistochemistry, Expressing